Diarrhea is a common side effect of misoprostol and has varying degrees of severity - from mild to severe, life-threatening. Older people lose fluids and minerals during diarrhea can lead to a drop in blood pressure or cause a malfunction of the heart, kidneys and impair mental state. Misoprostol may cause diarrhea in a significant number of patients who had not tolerate the drug. In clinical studies, diarrhea was observed in 14 - 40% of cases.Causes of diarrhea